“生命之述”系列讲座 2019-15 The Human X-linked Autism Protein KIDLIA/NEXMIF in Neurodevelopment and Brain Function

讲座人：满恒业 教授 波士顿大学

时间：10:00

日期：2019-07-05

地点：长安校区 格物楼3201会议室

内容简介：

X-linked KIAA2022/KIDLIA gene is a new autism gene. We have successfully created a KIAA2022 knockout mouse model which shows typical autism phenotypes as well as impairments in learning and memory. We find that loss of KIAA2022 results in suppression of dendritic growth, a decrease in spine number, synapse formation and synaptic transmission. We are investigating the underlying molecular mechanisms and also exploring means to rescue the molecular dysregulation and behavioral deficits in KIAA2022/KIDLIA knockout mice with the aim to provide therapeutic tools for clinical management of the disorder.

讲座人简介：

满恒业教授，美国波士顿大学生物系副主任、博士生导师，生物系终身教授。担任多家杂志包括Neuron、Nature Neuroscience等的审稿人，美国NIH、英国医学研究委员会等基金的评审。两次获得美国脑与行为基金会的青年科学家奖。主要科研方向包括突触生成及可塑性，谷氨酸受体动态分布及蛋白稳定性的调节机制，神经细胞形态发育，神经发育性和退行性疾病等的细胞分子机制。在多种杂志包括Nature、Science、Cell、Neuron、Cell Reports、J Neuroscience、PNAS等发表文章70余篇。